Researchers find BRAF protein modification could slow tumor growth

The protein BRAF is a key player in the development of many different types of cancer, including melanoma. Scientists have known that BRAF becomes activated by growth factors and subsequently stimulates downstream proteins that promote cancer cell growth, invasion and survival. However, less is understood about how BRAF is involved in communicating signals from pro-inflammatory cytokines that are released by immune cells in the surrounding tumor environment. Researchers in Moffitt Cancer Center's Donald A. Adam Melanoma and Skin Cancer Center of Excellence have discovered a signaling pathway between cytokines and BRAF that promotes tumor growth.
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