Structure and degradation of circular RNAs regulate PKR activation in innate immunity

Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing the exons of thousands of genes in eukaryotes. They are generally expressed at low levels and often exhibit cell-type-specific and tissue-specific patterns. The study of circRNAs, especially their function, is challenging due to their circular conformation and sequence-overlap with linear mRNA counterparts.
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